Homeostatic plasticity in neural development

Homeostatic synaptic plasticity: from single synapses to neural circuits

Homeostatic synaptic plasticity remains an enigmatic form of synaptic plasticity. Increasing interest on the topic has fuelled a surge of recent studies that have identified key molecular players and the signaling pathways involved. However, the new findings also highlight our lack of knowledge concerning some of the basic properties of homeostatic synaptic plasticity. In this review we address...

Homeostatic Synaptic Plasticity

Homeostatic synaptic plasticity mechanisms provide a means for neurons and circuits to maintain stable function in the face of perturbations such as developmental or activitydependent changes in synapse number or strength. These forms of plasticity use negative feedback signaling to adjust synaptic properties to keep activity close to some internal set point value. Recent work suggests that the...

Nonglobal homeostatic synaptic plasticity?

Neural plasticity and cognitive development.

It has been well documented that the effects of early occurring brain injury are often attenuated relative to later occurring injury. The traditional neuropsychological account of these observations is that, although the developing neural system normally proceeds along a well-specified maturational course, it has a transient capacity for plastic reorganization that can be recruited in the wake ...

Mechanisms of GABAergic Homeostatic Plasticity

Homeostatic plasticity ensures that appropriate levels of activity are maintained through compensatory adjustments in synaptic strength and cellular excitability. For instance, excitatory glutamatergic synapses are strengthened following activity blockade and weakened following increases in spiking activity. This form of plasticity has been described in a wide array of networks at several diffe...